Peptide 5 (Connexin 43) 5mg Product Information
Peptide 5 (Connexin 43) 5 mg research-grade lyophilized peptide powder supplied in a glass vial. Peptide 5, also known as αCT1 (alpha Connexin carboxyl-terminal 1), is a synthetic nonapeptide corresponding to the C-terminal sequence of Connexin 43 (Cx43) that is studied in experimental models of gap junction modulation, tissue repair and cell–cell communication. Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use. Purity 99%+ (HPLC, third-party tested) Form Lyophilized peptide powder Content 5 mg Peptide 5 (αCT1) per vial Packaging Glass vial with sterile closure Storage Store lyophilized at 2–8 °C (desiccated, protect from light) Molecular formula C47H78N14O16 Molecular weight ~1099.2 g·mol⁻¹ Sequence Arg-Pro-Arg-Pro-Asp-Asp-Leu-Glu-Ile CAS number 1373327-02-1 In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see Bacteriostatic water – 10 ml . Research Overview Peptide 5 (αCT1) is a synthetic nonapeptide corresponding to the final nine amino acids of the Connexin 43 (Cx43) C-terminus. In experimental in vitro and in vivo models it is used to investigate how targeted modulation of Cx43–ZO-1 interactions and gap junction organization can influence intercellular communication, barrier integrity and tissue repair processes in diverse organs and tissues. Primary Research Areas Gap junction modulation: used in studies examining how modulation of Connexin 43-containing gap junctions alters intercellular coupling, electrical conductance and signaling in cardiac, epithelial and other tissue models. Connexin 43 / ZO-1 interaction: applied to probe interactions between the Cx43 C-terminus and scaffolding proteins such as Zonula occludens-1 (ZO-1), and how these complexes regulate junctional organization and barrier properties. Wound healing and tissue repair models: investigated in skin, corneal and other injury models where altered gap junction communication and Cx43 distribution are linked to tissue repair dynamics and structural recovery endpoints. Cardiac protection and anti-arrhythmic research: used in preclinical cardiac models exploring whether targeted manipulation of Cx43-containing gap junctions can influence conduction heterogeneity, arrhythmia susceptibility and myocardial injury responses under controlled conditions. Cell–cell communication in diverse tissues: included in broader research on how connexin-based junctions coordinate cell behavior, growth and differentiation across epithelial, endothelial and other cellular networks.
