Orexin A 5mg (preorder) Product Information
Orexin A 5mg research-grade lyophilized peptide powder in a glass vial. This hypothalamic neuropeptide (also known as Hypocretin-1, Hcrt-1) is widely studied in experimental models of wakefulness, sleep–wake regulation, appetite control, energy balance and reward-related signaling. Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use. Purity 99%+ (HPLC, third-party tested) Test Certificate Available upon request (COA) Form Lyophilized peptide powder Content 5mg Orexin A per vial Packaging Glass vial with sterile closure Storage Store lyophilized at 2–8 °C in a dry place, protected from light. Molecular formula C152H252N44O44S2 Molecular weight ≈ 3,561.1 g·mol⁻¹ Sequence (human) Pyr-Gly-Leu-Ser-Ser-Ala-Ser-Ser-Arg-Ser-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Ser-Gly-Ala-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Leu-NH2 CAS number 205526-95-8 In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see Bacteriostatic water – 10 ml . Research Overview Orexin A 5mg is an endogenous hypothalamic neuropeptide derived from the prepro-orexin precursor and is one of the two orexin/hypocretin ligands alongside Orexin B. In experimental systems, Orexin A 5mg acts as a potent agonist at both Orexin Receptor 1 (OX1R) and Orexin Receptor 2 (OX2R), and is commonly used to probe sleep–wake circuitry, arousal states, feeding behavior, energy homeostasis and reward-related pathways in vitro and in vivo research models. Primary Research Areas Sleep–wake regulation and narcolepsy models: Used in laboratory studies investigating hypothalamic circuits that stabilize wakefulness and model narcolepsy-like phenotypes through dual OX1R and OX2R activation. Arousal and vigilance: Applied in experimental systems to examine orexinergic modulation of cortical activation, neuronal excitability and behavioral arousal. Appetite and energy balance: Studied in preclinical feeding and metabolic models to explore the influence of Orexin A 5mg on food intake, thermogenesis and metabolic signaling. Reward and motivation circuitry: Employed to investigate orexinergic regulation of mesolimbic dopamine pathways and reward-driven behaviors. Synaptic transmission and neuronal plasticity: Used in electrophysiological and imaging studies to characterize how Orexin A 5mg alters synaptic strength, firing patterns and network activity.
