MOTS-c Product Information
MOTS-c is a short, endogenously encoded peptide consisting of 16 amino acids and derived from a conserved mitochondrial genomic sequence. In laboratory research settings, MOTS-c is examined for its structural characteristics, intracellular localization patterns, and involvement in experimentally observed cellular signaling pathways under controlled conditions in non-human research models. Within experimental systems, MOTS-c has been observed to associate with cellular energy-related signaling networks, including pathways involving AMP-activated protein kinase (AMPK). Research investigations focus on characterizing how MOTS-c participates in intracellular signaling cascades, transcriptional responses, and pathway modulation when cells are subjected to defined experimental stressors. These studies emphasize pathway engagement, signaling dynamics, and molecular interactions rather than outcomes or physiological effects. Additional research explores how MOTS-c behaves within cellular environments that model altered energetic states, examining parameters such as gene expression patterns, intracellular compartment activity, and signaling pathway responsiveness. Experimental observations are used to better understand the peptide’s role as a signaling-associated molecule within controlled laboratory systems. MOTS-c is studied alongside other short peptides of mitochondrial genomic origin due to shared interest in intracellular communication and signaling behavior. These compounds differ in sequence, structure, and experimental application, and are evaluated using distinct research methodologies. Within non-human laboratory models, MOTS-c serves as a research tool for investigating signaling pathway engagement, molecular response patterns, and intracellular communication mechanisms under defined experimental conditions. Summary of Characteristics Characteristic Details Chemical Sequence of Amino Acids Tyr-Ala-Phe-Pro-Glu-Gln-Asp-Val-Gly-Gly-Tyr-Ser-Lys-Ser-Val-Met-Ser Molecular Formula C73H141N29O28S2 Molecular Weight 2117.24 g/mol Alternate Research Identifiers Open Reading Frame–Associated Peptide (ORF-derived), Research Peptide Identifier
