KY-19382 5 mg/ml – solution 30 ml Product Information
KY-19382 5 mg/ml – solution 30 ml research-grade small-molecule solution supplied in a 30 ml glass bottle. KY-19382 is a synthetic indirubin-derived compound studied as a dual modulator of the Wnt/β-catenin signaling pathway, described in the literature as inhibiting GSK3β activity and interfering with the CXXC5–DVL interaction in experimental models investigating bone growth, cartilage biology, metabolic regulation and hair-follicle regeneration. Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use. Purity High-purity research grade Form Clear research solution Content 5 mg KY-19382 per 1 ml; 30 ml per bottle (total 150 mg KY-19382 per bottle) Packaging 30 ml glass bottle with sterile closure Storage Store at 2–8 °C; protect from light. Molecular formula C17H11Cl2N3O2 Molecular weight 360.19 g·mol⁻¹ IUPAC name 2H-indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro CAS number 2226664-93-1 Research Overview KY-19382 is a synthetic indirubin-derived small molecule used as a tool compound in studies of Wnt/β-catenin signaling. In preclinical work it has been characterized as a dual modulator that can inhibit GSK3β activity and interfere with the CXXC5–DVL interaction, leading to enhanced Wnt/β-catenin pathway activity in selected experimental systems. Laboratory research employs KY-19382 in cell and tissue models focused on bone and cartilage growth, hair-follicle biology, metabolic regulation and other Wnt-dependent processes under strictly controlled conditions. Primary Research Areas Wnt/β-catenin pathway modulation: used in in vitro and in vivo models to study how dual modulation of GSK3β activity and the CXXC5–DVL interface impacts β-catenin stabilization, nuclear translocation and transcriptional activation of Wnt target genes in development and regeneration research. Bone growth and cartilage / chondrogenesis models: applied in studies of growth plate biology, chondrocyte proliferation and differentiation, and longitudinal bone growth, where altered Wnt/β-catenin signaling is examined in the context of skeletal development and age-related growth plate senescence. Hair follicle and skin regeneration research: incorporated into experimental systems investigating hair-follicle cycling, hair shaft elongation and dermal regeneration, including models where Wnt/β-catenin signaling activators are evaluated under metabolic or hyperglycemic stress conditions. Metabolic and endocrine signaling models: used as a probe compound in studies exploring how modulation of Wnt/β-catenin signaling intersects with pathways relevant to metabolic homeostasis, glucose handling and adipocyte or hepatocyte biology in preclinical settings. Wnt-dependent disease and oncology research: evaluated in cell and tissue models of Wnt-related pathologies, including fibrosis and selected tumor systems, where dysregulated Wnt/β-catenin activity is a key mechanistic focus of laboratory investigation.
