GLP-1 (SM) Product Information
GLP-1 (Sm) is a synthetic peptide analog evaluated in laboratory and preclinical research settings for its structural interaction with glucagon-like peptide-1 (GLP-1) receptor pathways in non-human experimental models. The compound consists of 31 amino acids and incorporates specific structural modifications, including substitution of alanine with α-aminoisobutyric acid at position 8, which has been studied for its effect on resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4) in analytical environments. An additional acyl modification involving a hexadecanedioic acid moiety has been characterized for its role in albumin-binding affinity and altered pharmacokinetic behavior under controlled research conditions. In controlled laboratory and preclinical models, GLP-1 (Sm) is utilized to examine receptor binding characteristics, signaling pathway engagement, and downstream biochemical signaling associated with GLP-1 receptor interaction in non-human test subjects and in vitro assay systems. Its defined molecular structure supports analytical investigation of peptide stability, receptor specificity, and signaling duration within standardized experimental frameworks. Due to its characterized structural and receptor interaction profile, GLP-1 (SM) is employed as a reference compound in non-clinical research focused on peptide-receptor dynamics and pathway signaling analysis in laboratory-based, non-human research settings. Summary of Characteristics Characteristic Details Chemical Sequence of Amino Acids His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly with a C18 fatty diacid (hexadecanedioic acid) acylated via a spacer at Lys26 CAS Number 910463-68-2 Molecular Formula C187H291N45O59 Molecular Weight 4,113.58 g/mol Other Known Titles GLP-1 analog; NN9535 (research designation)
